Based on scientific researches which has been performed in continuation of widely using of Saffron in traditional and plant medicine, the various properties of Saffron and effective composition have attracted the attention of many more researchers, pharmaceutics, and active in medical sciences. The results of these researches in different countries of the world show the Saffron will be an important replacement of chemical drugs which the researchers know the Saffron as the point of reference in using the pharmaceutical industry in near future.